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Analysis of patient adherence to treatment by DOAC I
Rezáková, Katarína ; Malý, Josef (advisor) ; Smejkalová, Lenka (referee)
Analysis of patient adherence to treatment by DOAC I Author: Katarína Rezáková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Kateřina Malá, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Atrial fibrillation (AF) is the most common supraventricular tachyarrhythmia associated with increased morbidity and mortality. In clinical practice, direct oral anticoagulants (DOAC) are used as an alternative to warfarin to prevent thromboembolic events in patients with AF. The study aimed to analyse the statements of patients with FiP along with data from medical records focusing on aspects related to the use and management of DOAC, including devices and tools to improve adherence to treatment, patients' level of awareness of DOAC and other therapeutic agents used. Methods: The prospective study was conducted from 2020 to 2022 at the University Hospital Brno. Patients aged ≥ 18 years with AF on DOAC therapy (dabigatran, rivaroxaban and apixaban) were included in the study. Data about pharmacotherapy and patients' health status were obtained from medical records and structured interview with the patient. Patients' interviews were performed at time 0, three and six months after patient has entred the study....
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Analysis of patient adherence to treatment by DOAC II
Janáčková, Natália ; Malý, Josef (advisor) ; Hendrychová, Tereza (referee)
6 Abstract Analysis of patient adherence to treatment by DOAC II Author: Natália Janáčková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Simona Dvořáčková, Ph.D., Mgr. Eliška Mašková Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Dosing interval may be an important factor influencing adherence to direct oral anticoagulant (DOAC) therapy. In terms of adherence, a once-daily regimen appears to be a better alternative. However, there may be a higher risk of treatment failure if the dose is missed. The aim of the practical part of the thesis was to analyse patients' attitudes and experiences with DOACs, complemented by data from medical records, with a focus on aspects related to DOAC dosing. Methods: Data collection for this prospective study was carried out from 2020 to 2022 at the Internal Cardiology Outpatient Clinic of the University Hospital in Brno. Patients aged ≥ 18 years on DOAC treatment with indicated atrial fibrillation (FS) were approached to participate in the study. Each patient underwent a structured interview with a trained pharmacist on the day of study entry and again after 3 and 6 months. Two validated and three supplementary questionnaires were used in the interview. Patients' attitudes, experiences...
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Pharmacists` attitudes towards direct anticoagulants
Mertová, Tereza ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
Pharmacists' attitudes towards direct anticoagulants Author: Tereza Mertová Supervisor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Kateřina Malá, Ph.D. Charles University, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Introduction and Objective: Pharmacists are involved in providing of professional information about direct oral anticoagulants (DOAC) treatment during DOAC dispensation to patients. Their attitudes and knowledge about DOAC treatment are therefore crucial for optimisation of pharmaceutical care of patients taking DOAC. The objective of this thesis was to analyze attitudes, experience, habits and opinions of pharmacists regarding the DOAC treatment. Methodology: Pharmacists from three District Pharmacists' Associations (OSL) were addressed to participate in an electronic anonymous questionnaire between March and May 2021. Questionnaire consisted of 32 items focusing on the frequency of DOAC dispensation, pharmacist self-confidence about DOAC, information provided to patients during DOAC dispensation, benefits and limits of DOAC treatment compared to treatment with warfarin, and patient adherence to DOAC treatment. The results were processed using descriptive statistics and further analyzed by parametric and nonparametric tests. Results: A...
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